Brandon dekosky

Congratulations to Brandon DeKosky, who has been promoted to Associate Professor Without Tenure in MIT Chemical Engineering (ChemE), effective July 1! Liked by Anthony DiBuono Collaborate.

<u>Position Overview:</u><br><br>The DeKosky Laboratory for Immune Engineering and Drug Discovery ((Use the "Apply for this Job" box below). Google Scholar: ) is seeking to grow in the hiring of a new postdoctoral researcher to apply high-throughput T cell receptor functional analysis against cancers and viral infections. These efforts will advance basic understanding of T cell <b ...Comprehensive molecular and functional analyses of anti-HIV-1 broadly neutralizing antibody repertoires Dekosky, Brandon JamesBrandon DeKosky is an assistant professor at MIT, jointly between the Department of Chemical Engineering and the Ragon Institute of MGH, MIT, and Harvard. Brandon received a BS in chemical engineering from University of Kansas and a Hertz-supported PhD in chemical engineering from the University of Texas at Austin.Starting Fall 2021, Brandon DeKosky will be joining the MIT Chemical Engineering Department in a newly introduced joint faculty position between the department and the Ragon Institute of MGH, MIT and Harvard, which seeks to address infectious disease by harnessing the human immune system.CCPS Center for Chemical Process Safety ; RAPID RAPID Manufacturing Institute ; DIPPR Design Institute for Physical Properties ; SBEBrandon J. DeKosky joined the Department of Chemical Engineering as an assistant professor in a newly introduced joint faculty position between the department and the Ragon Institute of MGH, MIT, and Harvard in September 2021. He received his BS in chemical engineering from University of Kansas and his PhD in chemical engineering from the ...Dr. Brandon DeKosky Recommended Citation Duggan, Eli M.; Oliveira de Souza, Matheus; and Hatungimana, Brunojoel, "Anti-HIV Antibody Optimization via Site Saturation Mutagenesis" (2022).

3.2.1 Device Construction. For facile high-throughput single-cell manipulation we assembled a simple axisymmetric flow-focusing device comprising three concentric tubes: an inner needle carrying cells suspended in PBS, a middle tube carrying a lysis solution and magnetic poly(dT) beads for mRNA capture from lysed cells, and finally an external tube with a rapidly flowing annular oil phase, all ..."Whenever he's looking at taking on a new project, he does this check to see if it's worthwhile and if somebody would want to use it," says Brandon DeKosky, one of Georgiou's graduate research assistants. "That's the driving force behind why so much of his work gets out there he makes sure whatever he's working on is going to be ...Keynote Speaker Brandon DeKosky, PhD Professor of Chemical Engineering, Massachusetts Institute of Technology (MIT) His research group contributes to the incredible expansion in quantitative biotechnology and drug development, making discoveries in an exciting field that continues to evolve.Brandon DeKosky Massachusetts Institute of Technology; The Ragon Institute Verified email at mit.edu. Gregory C. Ippolito The University of Texas at Austin Verified email at austin.utexas.edu. ... BJ DeKosky, GC Ippolito, RP Deschner, JJ Lavinder, Y Wine, ... Nature biotechnology 31 (2), 166-169, 2013. 495:Brandon J. DeKosky, Assistant Professor, The University of Kansas , Lawrence, K S 9:40 AM to 10:10 AM Lessons Learned from the MHC II Immunopeptidome Laura Santambrogio, MD, PhD, Professor of Pathology, Immunology and Microbiology Albert Einstein College of Medicine, New York, NY BREAK 10:10 AM to 10:25 AMDekosky BJ, Lungu OI, Park D, Johnson EL, Charab W, Chrysostomou C, et al. Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires. Proc Natl Acad Sci U S A (2016) 113 (19):E2636. 10.1073/pnas.1525510113 [PMC free article] [Google Scholar]"Whenever he's looking at taking on a new project, he does this check to see if it's worthwhile and if somebody would want to use it," says Brandon DeKosky, one of Georgiou's graduate research assistants. "That's the driving force behind why so much of his work gets out there he makes sure whatever he's working on is going to be ...

Dimitris Skokos, Conference and exhibition covering antibodies, immunotherapy, and clinical trials. 350+ speakers, 60+ exhibitors.Brandon DeKosky Associate Professor at MIT and The Ragon Institute/MGH 1y Report this post Great job Oscar! So excited to have you working with us!! Ragon ...Brandon DeKosky Research Interests biotechnology, vaccines, molecular immunology, single cell analysis, antibodies, t cell receptors, immune biomaterials, protein drug developmentCongratulations to KI members Michael Birnbaum, Ömer Yilmaz, Brandon DeKosky and Regina Barzilay, along with their MIT colleague Seychelle Vos, on… Liked by Yuyan Cai

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Monoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine, however, the repeated administration of mAbs can be highly immunogenic. Drug immunogenicity manifests in the generation of anti-drug antibodies (ADAs), and some mAbs show immunogenicity in up to 70% of patients. ADAs can alter a drug’s pharmacokinetic and pharmacodynamic properties, reducing drug efficacy ...Brandon DeKosky Associate Professor at MIT and The Ragon Institute/MGH Cambridge, MA. Virginia Maxwell Senior Associate Producer, Conferences at Cambridge Healthtech Institute ...Brandon DeKosky - Associate Professor of Chemical Engineering - Massachusetts Institute of Technology | LinkedIn. Associate Professor at …Brandon J. DeKosky. I really enjoy the environment for immunology and biotech research here at Ragon, MIT, and Cambridge, there are so many incredibly talented people to work with and learn from! Outside of the lab I enjoy swimming, soccer, playing jazz piano, and exploring live music around Cambridge and Boston.

170. 2010. Ultra-high-throughput sequencing of the immune receptor repertoire from millions of lymphocytes. JR McDaniel, BJ DeKosky, H Tanno, AD Ellington, G Georgiou. Nature protocols 11 (3), 429-442. , 2016. 148. 2016. Functional interrogation and mining of natively paired human V H :V L antibody repertoires.Selective chemical reactions that are orthogonal to the diverse functionality of biological systems have become important tools in the field of chemical biology. Two notable examples are the Staudinger ligation of azides and phosphines and the Cu(I)-catalyzed [3 + 2] cycloaddition of azides and alkynes ("click chemistry"). The Staudinger ligation has sufficient biocompatibility for ...Brandon J DeKosky 1 , Takaaki Kojima 2 , Alexa Rodin 1 , Wissam Charab 1 , Gregory C Ippolito 3 , Andrew D Ellington 4 , George Georgiou 5 Affiliations 1 Department of Chemical Engineering, University of Texas at Austin, Austin, Texas, USA. Brandon DeKosky. Brandon J. DeKosky joined the Department of Chemical Engineering as an assistant professor in a newly introduced joint faculty position between the department and the Ragon Institute of MGH, MIT and Harvard in September 2021.Denise Lau 1 , Linda Yu-Ling Lan 1 , Sarah F Andrews 2 , Carole Henry 2 , Karla Thatcher Rojas 2 , Karlynn E Neu 1 , Min Huang 2 , Yunping Huang 2 , Brandon DeKosky 3 , Anna-Karin E Palm 2 , Gregory C Ippolito 4 , George Georgiou 3 4 5 , Patrick C Wilson 6 2ebolaviruses using B cells from immunized macaques. Our filovirus expertise is complemented by Dr. Brandon DeKosky who has developed an unparalleled methodology for large-scale interrogation of functional B cell repertoire and high throughput cloning and display of natively paired VH:VL sequences. This unique system willJanet Louise Koperski DeKosky, beloved mother and grandmother, passed away unexpectedly but peacefully on March 28, 2023 at her home in Overland Park, Kansas. Janet was born in Grand Rapids, Michigan on January 23rd 1940. She grew up in a large Polish and Dutch family built around hard work, faith, and love.Apr 1, 2010 · Home About Select to follow link Visit Us Our Mission Outreach and Events Brandon DeKosky's project will reveal insights related to the role of antibody-based protection against SARS-CoV-2 lung injury and help accelerate new medical interventions to suppress the global COVID-19 pandemic.

Feb 28, 2022 · Brandon J. DeKosky joined the Department of Chemical Engineering as an assistant professor in a newly introduced joint faculty position between the department and the Ragon Institute of MGH, MIT, and Harvard in September 2021. He received his BS in chemical engineering from University of Kansas and his PhD in chemical engineering from the ...

Journal Reference:. Bo Wang, Brandon J DeKosky, Morgan R Timm, Jiwon Lee, Erica Normandin, John Misasi, Rui Kong, Jonathan R McDaniel, George Delidakis, Kendra E Leigh, Thomas Niezold, Chang W ...With a recent $1.8 million, five-year grant from the National Institutes of Health, Brandon DeKosky's lab is using high-throughput techniques to analyze the behavior of B cells in the body.Developed protein production and high throughput sequencing skillsets in the Brandon DeKosky laboratory. Madison and Lila Self Graduate Fellow The University of Kansas Aug 2015 - Dec ...Brandon DeKosky, PhD, Assistant Professor, The University of Kansas . 1:45 KEYNOTE PRESENTATION: Predicting Immunogenicity of Biopharmaceuticals Through Integrating in silico, in vitro, and Immune Systems Data. Timothy Hickling, PhD, Immunogenicity Sciences Lead, Pfizer Inc.By contrast, previous studies have shown that only about 10 percent of the antibodies generated using techniques that rely on the random pairing of heavy- and light-chain genes are antigen-specific, says Brandon DeKosky, a graduate student in the Georgiou lab who helped to develop the technique. Pros: Very fast.Proud! Immensely proud. Antibody biologists and engineers and others interested in this topic: just read this conceptual review on a topic we are very… | 22 comments on LinkedInWe developed a new high-throughput approach to enable repertoire-scale functional evaluations of natively paired TCRs. In particular, we leveraged the immortalized nature of physically linked TCRα:β amplicon libraries to analyze binding against multiple recombinant pMHCs on a repertoire scale, and to exemplify the utility of this approach, we ...4.2.1 VH:VL Gene Usage Across B Cell Subsets. We analyzed the peripheral blood antibody repertoire of three human donors using the single B cell VH:VL sequencing technique reported and described in Chapter Four [].Peripheral blood mononuclear cells (PBMC) isolated from three human donors were sorted by FACS to discriminate CD3 − 19 + 20 + 27 − naïve B cell and CD3 − 19 + 20 + 27 ...

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Monoclonal antibodies (mAbs) are an important class of therapeutics used to treat cancer, inflammation, and infectious diseases. Identifying highly developable mAb sequences in silico could greatly reduce the time and cost required for therapeutic mAb development. Here, we present position-specific scoring matrices (PSSMs) for antibody …Labs. The Ragon Institute brings together diverse researchers from across Mass General, MIT, and Harvard. Below, you will find our Core Members and faculty primarily located at the Ragon. Our community also includes Associate Members, frequent collaborators whose work is done at another institute, and Steering Committee Members, collaborators ...Dr. Brandon DeKosky Lab, University of Kansas—Department of Pharmaceutical Chemistry (Lawrence, KS) • Optimized a PCR-based site-directed mutagenesis method for rapidly and effectively mutating antibody sequences. o Designed mutagenic primers and introduced site-directed mutations into antibodyKlavs F. Jensen, Karen Gleason, Yuriy Roman, and Brandon DeKosky Cambridge, MA. Connect Show more profiles Show fewer profiles Explore collaborative articles ...Free essays, homework help, flashcards, research papers, book reports, term papers, history, science, politicsNew antibodies against malaria Highly protective anti-malarial antibodies via precision yeast display library generation and screening. Banach BB, Tripathi P, Pereira L, Gorman J, Nguyen TD, Dillon M, Fahad AS, Kiyuka P, Madan B, Wolfe JR, Bonilla B, Flynn B, Francica JR, Hurlburt NK, Liu T, Ou L, Rawi R, Schön A, Shen C-H, Teng I-T, Zhang B, Pancera M, Idris AH, Seder RA, Kwong PD, DeKosky B Congratulations to Dr. Brandon DeKosky, the 2022 James S. Huston Antibody Science Talent Award recipient! This award is given annually by The Antibody Society to an early career researcher who has made important contributions to antibody science. DeKosky and his lab have developed a suite of high-throughput single-cell platforms for large-scale ...12.10.2022 г. ... This research will provide important insights into new treatment targets and approaches. Brandon DeKosky, PhD. Massachusetts General Hospital.To maintain its multidisciplinary character and central research focus, the CMBE SIG is committed to supporting new investigators within the field. Towards this goal, the "Rising Star" award has been given to a select group of exceptional junior principal investigators each year. Awardees provide a podium presentation in a special session ... ….

Brandon J. DeKosky - Immune Engineering Lab B cell receptors, T cell receptors, single-cell analysis, infectious diseases, high-throughput screening, infectious diseases, cancer therapeutics. Current Projects: High-throughput antibody screening technologies and computational approaches for rapid drug discovery The current low-throughput ...Graduate students who participate (left to right): Apollo Stacy, Dr. Greg Clark, Aimee Wessel, Inga Jarmoskaite, Brandon DeKosky, Peter Enyeart, Josh Russell, Marisa Miller, Gabriel Wu, Stephanie Taylor, Damon Polioudakis, Brant Gracia Photo by Marsha MillerAntibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being expedited through preclinical and clinical development. Data from the study of SARS-CoV and other respiratory viruses suggest that anti-SARS-CoV-2 antibodies could exacerbate COVID-19 through antibody-dependent enhancement (ADE).New antibodies against malaria Highly protective anti-malarial antibodies via precision yeast display library generation and screening. Banach BB, Tripathi P, Pereira L, Gorman J, Nguyen TD, Dillon M, Fahad AS, Kiyuka P, Madan B, Wolfe JR, Bonilla B, Flynn B, Francica JR, Hurlburt NK, Liu T, Ou L, Rawi R, Schön A, Shen C-H, Teng I-T, Zhang B, Pancera M, Idris AH, Seder RA, Kwong PD, DeKosky BMar 8, 2022 · Brandon J. DeKosky joined the Department of Chemical Engineering as an assistant professor in a newly introduced joint faculty position between the department and the Ragon Institute of MGH, MIT and Harvard in September 2021. He received his BS in chemical engineering from University of Kansas, and his PhD in chemical engineering from the ... We thank Nicole Doria-Rose for useful discussion on the methods for isolating monoclonal antibodies, James Cunningham for support, Soo-mi Lee for help purifying probes, Ulrich Baxa for tips on sample preparation for electron microscopy, Kendra Leigh for critical review, and Brandon DeKosky, Amy Ransier, and Sam Darko for discussion on the ...Comprehensive molecular and functional analyses of anti-HIV-1 broadly neutralizing antibody repertoires Dekosky, Brandon JamesBrandon DeKosky. Phillip and Susan Ragon Career Development Professor of Chemical Engineering. Patrick S. Doyle. Robert T. Haslam (1911) Professor of Chemical Engineering, Singapore Research Professor. Lawrence B. Evans. Professor Emeritus. Ariel L. Furst Paul M. Cook Career Development Professor ... Brandon dekosky, [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1]